A simple, precise, accurate UV Spectroscopic method has been developed for estimation of capecitabine in pure and pharmaceutical dosage form. UV -spectroscopic method which is based on measurement of absorption of UV light, the spectra of capecitabine in glass distilled water showed maximum wavelength at 302 nm and calibration graphs were plotted over the concentrations ranging from 10-60 �µg/ml-1 of capecitabine with correlation coefficient 0.9996. Validation was performed as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.16 and0.456 respectively by simple UV spectroscopy.
Loading....